The use of shelves in base cabinets is poor ergonomics: It makes it very difficult to find items as it is impossible to gain an overview of the entire cabinet contents. It is quite common for a kitchen user to have to bend and stretch when searching for something. Equally they frequently have to remove the contents at the front in order to get to the items at the back.
The final choice if you are replacing odd sized drawer knobs is to buy ones with a back plate. A back plate can cover the existing holes. No one will know they are there. It will eliminate the problem inherent in the other option where you have to match the finish of the holes to the drawer front. Many drawer pulls come with back plates.
To choose drawer knobs that will fit the holes that have already been drilled for previous hardware, it is essential to do some measuring. Take off the old drawer pull and measure from the center of one screw hole to the center of the other. A three-inch distance is quite common and it will be easy to find a replacement.
We had the contractors start the parade - looking at the layout of the kitchen and the cabinet construction, the overall construction of the house and the kitchen in particular. The bids came in - slowly at first and then in a deluge. The prices were astounding. This was in the early 1980's and the low bid was $12,000, and that was for a new sink, paint and "new cabinet facings" (new doors on the existing cabinets!) Now the house was not inexpensive, but these prices were out of sight! Times were much like today, many people out of work and contracts were few and far between.
You can search the home improvement stores and hardware stores looking for that ideal set of cabinet handles. It takes a lot of leg work, but you get a first hand look at any hardware you are considering. If it is a local store, you are likely to know how good their return policies are, as well.
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